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About SPRAVATO (esketamine) Treatment

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth, to treat:

  • Adults with treatment-resistant depression (TRD)

  • Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions


How does SPRAVATO Work?

SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.


What to Expect During your 
SPRAVATO  Treatment

  • You will not be able to drive, so plan transportation for treatment days. 

  • You will administer the nasal spray yourself under the supervision of a healthcare provider.

  • You Will be monitored for side effects for at least two hours.

  • Your healthcare provider will tell you when it's OK to leave.

  • Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.

Spravato Patient Education video

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